Trifluoroacetic Anhydride

Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.

A simplified procedure for the synthesis of short acyl chain phosphatidylcholines is described. A mixed fatty acid-trifluoroacetic anhydride is used to acylate sn-glycero-3-phosphocholine (GPC) which has been dissolved in trifluoroacetic acid. Yields exceeding 70% are achieved in 30-min reaction time using 1.5 to 2.0 equivalents of mixed anhydride per, GPC hydroxyl. This allows a more economica...

Chemistry of Pyrrolizines; Reactions with Cyanogen Bromide and Trifluoroacetic Anhydride

-Interaction of the pyrrolizine 3 with cyanogen bromide in a tetrahydrofuran/water mixture affords addition to the enamine double bond with formation of 5 which can be aromatized to 6 by silica gel. Reaction of 6 with cyanogen bromide in the same solvent mixture yields the indoline 8a which structure is proved in a chemic/d way by conversion of the product into the aldehyde 8(1. The different r...

Nucleophilic addition to N-phosphinylimines by rare-earth-metal triflate/trifluoroacetic anhydride activation.

MRI of trifluoroacetic acid encapsulated into liposomes

within ~9min. The slice thickness is 10mm and the resolution is 0.125cm/pix. The resulting SNR is about 7.4. Fig. 2: Determination of the detection limit. The SNR is plotted for different concentrations of the liposomes. The red line shows the theoretical SNR normalised to the highest concentration. Fig. 1: Spectra of the liposomes after washing (bottom) and the corresponding supernatant of the...

Trifluoroacetic Acid as a Peptide Solvent*

A method employing reverse phase high performance liquid chromatography has been developed for the purification of large denatured peptides. The cyanogen bromide fragments of hemoglobin a, 8, and y chains (13 to 91 residues in length) could be separated and recovered in 71 to 95% yields using LiChrosorb C-8 columns and a binary solvent system consisting of 0.013 M trifluoroacetic acid in water ...